Merah, A.Abidi, A.Chaffai, N.Bataille, B.Gherraf, N.2022-04-282022-04-282013http://hdl.handle.net/123456789/13037The present study deals with the influence of hydroxypropylmethylcellulose 4000 in the protection of Piroxicam polymorphs which could appear during the processes of formulation of extended release tablets. The physico-chemical tests and the dissolution profiles of polymorphs and tablets showed that the metolose incorporated in the tablets at a rate equivalent to 5% could possibly act doubly; initially by protecting the piroxicam polymorphism transition (form II) during compression, then modulating its in vitro release (extended release).enPiroxicamPolymorphismHydroxypropylmethylcellulose 4000CrystallizationExtended releaseArticle