Role of hydroxypropylmethylcellulose (HPMC 4000) in the protection of the polymorphs of piroxicam extended release tablets

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dc.contributor.authorMerah, A.
dc.contributor.authorAbidi, A.
dc.contributor.authorChaffai, N.
dc.contributor.authorBataille, B.
dc.contributor.authorGherraf, N.
dc.date.accessioned2022-04-28T01:30:24Z
dc.date.available2022-04-28T01:30:24Z
dc.date.issued2013
dc.description.abstractThe present study deals with the influence of hydroxypropylmethylcellulose 4000 in the protection of Piroxicam polymorphs which could appear during the processes of formulation of extended release tablets. The physico-chemical tests and the dissolution profiles of polymorphs and tablets showed that the metolose incorporated in the tablets at a rate equivalent to 5% could possibly act doubly; initially by protecting the piroxicam polymorphism transition (form II) during compression, then modulating its in vitro release (extended release).ar
dc.identifier.urihttp://hdl.handle.net/123456789/13037
dc.language.isoenar
dc.publisherSpringerar
dc.subjectPiroxicamar
dc.subjectPolymorphismar
dc.subjectHydroxypropylmethylcellulose 4000ar
dc.subjectCrystallizationar
dc.subjectExtended releasear
dc.titleRole of hydroxypropylmethylcellulose (HPMC 4000) in the protection of the polymorphs of piroxicam extended release tabletsar
dc.typeArticlear
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