Role of hydroxypropylmethylcellulose (HPMC 4000) in the protection of the polymorphs of piroxicam extended release tablets
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Date
2013
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Abstract
The present study deals with the influence of hydroxypropylmethylcellulose 4000 in the
protection of Piroxicam polymorphs which could appear during the processes of formulation of
extended release tablets.
The physico-chemical tests and the dissolution profiles of polymorphs and tablets showed that
the metolose incorporated in the tablets at a rate equivalent to 5% could possibly act doubly; initially
by protecting the piroxicam polymorphism transition (form II) during compression, then
modulating its in vitro release (extended release).
Description
Keywords
Piroxicam, Polymorphism, Hydroxypropylmethylcellulose 4000, Crystallization, Extended release