The evaluation the anti SARS COV-2 of bio active molecules from Algerian fir (Abies numidica de Lannoy) needlesin silico

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dc.contributor.authorBenouchenne, Djamil
dc.contributor.authorBellil, Inès
dc.contributor.authorKhelifi, Douadi
dc.date.accessioned2025-05-14T18:06:49Z
dc.date.available2025-05-14T18:06:49Z
dc.date.issued2021-12-13
dc.description.abstractBackground: plants containa huge number and amounts of secondary metabolites that have a beneficial effect on human health. In recent time, there is a great deal of attention on the use of plant extracts as an alternative drugs, to reduce the adverse effect of synthetic one. To reduce time and money bioinformatic tools become necessary.Algerian fir or Abies numidica is an endemic plant, found only in Babor's mounts. Used in folk medicine as an anti-inflammatory, to treat cataplasm and dissolve the respiratory system problems. Objective: the aimof our research is the prediction of the antiviral (anti SARS COV-2) effect of bioactive moleculesdetermined in Abies numidica leaves extracts using in silico tools. Material and methods: molecules determinedby LC-MS/MS analysis in ethyl acetate and n-butanol fractions were taken and analysed in silico. Different programs and servers were used as Hyperchem, Avogadro, Mopac, Dockthor to optimize and visualize the interactions between biomolecules and main protease (Mpro) of SARS COV-2. Results: results revealed that hyperoside and quercitrin presented a strong inhibitory ability agains SARS COV-2 virus, with an energy of interaction of -8.8 kcal/mol. Conclusion: more studies are needed to find and discover new biological products from natural ressources inorder to avoid side effects of synthetic one.
dc.identifier.isbn978-9931-9827-4-6
dc.identifier.urihttp://dspace.univ-oeb.dz:4000/handle/123456789/22414
dc.language.isoen
dc.publisherUniversity of Oum El Bouaghi
dc.subjectAbies numidica leaves; Ethyle acetate extract; N-Butanol fraction; Anti SARS COV-2; In silico tests
dc.titleThe evaluation the anti SARS COV-2 of bio active molecules from Algerian fir (Abies numidica de Lannoy) needlesin silico
dc.title.alternativeeffet protecteur de la luteoline.
dc.typeImage
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1er séminaire national sur la biothéchnologie des plantes médicinales et leur implication dans l'industrie pharmaceutique et alimentaire (BPMIPA) le 13-14 Décembre 2021