In vitro study of neuroprotective activity of tamarix africana seeds extracts.
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Date
2021-12-13
Journal Title
Journal ISSN
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Publisher
University of Oum El Bouaghi
Abstract
Tamarix Africana belongs to the Tamaricaceae family, there are more than 60 kinds of halophyte plants. Thisplantis commonly used in traditional Algerian medicine to treat many health problems.Enzyme inhibition is a common and important method for discovery of new drugs and treatment of human public disorders. There are several enzymes whose inhibition are considered a target for the treatment or prevention of related diseases, including cholinesterase' s (Alzheimer's disease). Due to the increasing attention in the valorization of endemic plants to support their use in the pharmaceutical, cosmetic, and food industry, the methanol and n-butanol extracts of seeds from Tamarix Africanawere investigated in neuroprotective activity. The air-dried powdered seedswere macerated in methanol (80%). After that the crude methanolic extract was fractionated using different solvents with increased polarities starting with ethyl-acetate followed by n-butanol. The methanolic and n-butanol extracts were taken to evaluate their neuroprotective effects using microplate method. As result, this plant extracts disclosed a potential activity against acetylcholinesterase (AChE) and buthyrylcholinesterase (BChE) using galantamine as standards, Consequently, the methanolic extract showed (IC5=44.38±1.87μg/ml) against (AChE) and a (IC50 = 18.60±1.09 μg/ml) against (BChE). On the other hand, the n-butanol fraction showed a (ICs 187.47±2.99 μg/ml) against (AChE) and a (IC-48.31±1.78 μg/ml) against (BChE). Plant extracts are being used to meet needs and overcome the challenges of finding and developing more reliable therapeutic substances with Minimal adverse effect.
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Keywords
In vitrostudy; Neuroprotective; Seedsextracts; Tamarix; Africana.